In anatomy and physiology, a duct is a circumscribed channel leading from an exocrine gland or organ. In humans, the system accounts for 4-5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. Function. Intercalated / Striated Ducts. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status. Intercalated ducts are small, short ducts which drain individual secretory units. Duct; Dissection of a lactating breast. CD principal cells traditionally have been considered to have a major role in Na + and water regulation, while intercalated cells (ICs) were thought to largely modulate acid-base homeostasis. (Redirected from Intercalated duct. intercalated duct: Any of several short, narrow ducts that lie between the secretory ducts and the terminal alveoli in the parotid and submandibular glands and in the pancreas. The epithelium of the kidney collecting duct (CD) is composed mainly of two different types of cells with distinct and complementary functions. For the purpose of describing duct structure and function, some special terminology can be useful. Function of Renal Intercalated Cells in Acid-Base Regulation Intercalated cells are enriched in mitochondria, and express proteins involved in transport of proton equivalents such as vacuolar H+-ATPase, carbonic anhydrase II and bicarbonate transporters [1,18]. These ducts continue on as striated ducts. The excurrent duct system of parotid and submandibu-lar salivary glands consists of intercalated duct (ID), stri-ated duct (SD), excretory duct, and main excretory duct (MED) (Tandler, 1993a); in many species of rodents, a further duct segment, the granular convoluted tubule (granular duct), is interposed between intercalated and These have a folded basal membrane, to enable active transport of substances out of the duct. These characteristics suggest a role for these cells in acid-base regulation [19]. types of ducts intercalated ducts striated ducts excretory ducts intercalated ducts smallest ducts oin the glands connect the scretory end pieces to striated ducts histology functions contribute macromolecular (lyzozimes, lactoferrin, unknown components). 3. The collecting duct system is the last component of the kidney to influence the body's electrolyte and fluid balance. See also: duct The secretory units merge into intercalated ducts, which are lined by simple low cuboidal epithelium, and surrounded by myoepithelial cells. The intercalated cells come in two different varieties: alpha-intercalated cells (which secrete acid) and beta-intercalated cells (which secrete base). undifferentiated salibary stem cells are thought to be present in intercalated ducts. Function The hormones of the endocrine pancreas are the primary regulators of glucose, lipid and protein metabolism. The collecting duct has two types of cells: principal cells (the aldosterone-responsive, ENac-expressing cells which also mediate water reabsorption via ADH) and the intercalated cells. A second feature is the intercalated ducts of the pancreas, which start from within the acinus rather than being a continuation of the acinus, like seen in other glands. At times of extreme dehydration, over 24% of the filtered water may be reabsorbed in the collecting duct system. Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. (By and large, the distinctions that these terms allow represent minor details rather than essential knowledge.) activated sA C in intercalated cel l function is also supp orted in cases of increase d chronic luminal bicarb onate delive ry (over days) to the colle cting duct (79). The intercalated cell of collecting ducts of the kidney is of two forms, the α form secretes acid, whereas the β form secretes HCO 3.Here, we review recent work that shows that the α form is derived from the β form and that the pathway is mediated …

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